Structurally?Diverse Sesquiterpenoids with Anti-neuroinflammatory Activity from the Endolichenic Fungus Cryptomarasmius aucubae

摘要

Graphic Abstract Two new sterpurane sesquiterpenoids named sterpurol D ( 1 ) and sterpurol E ( 2 ), and one skeletally new sesquiterpene, cryptomaraone ( 3 ), bearing a 5,6-fused bicyclic ring system, along with five known ones, sterpurol A ( 4 ), sterpurol B ( 5 ), paneolilludinic Acid ( 6 ), murolane-2 α , 9 β -diol-3-ene ( 7 ) and (–)-10,11-dihydroxyfarnesol ( 8 ) were isolated from an endolichenic fungus Cryptomarasmius aucubae . The structures of the new compounds were elucidated by analysis of NMR spectroscopic spectra and HRESIMS data. The absolute configurations of 1 and 2 were established by spectroscopic data analysis and comparison of specific optical rotation, as well as the biosynthetic consideration. Additionally, compounds 1 , 2 , 4 – 6 , and 8 showed significant nitric oxide (NO) production inhibition in Lipopolysaccharide (LPS)-induced BV-2 microglial cells with the IC _(50) values ranging from 9.06 to 14.81? μ M. Supplementary Information The online version contains supplementary material available at 10.1007/s13659-021-00299-9.