Differential miRNA plasma profiles associated with the spontaneous loss of HIV‐1 control: miR‐199a‐3p and its potential role as a biomarker for quick screening of elite controllers

摘要

People living with HIV (PLWH) who are able to main- tain suppressed viral load (VL) for years in the absence of antiretroviral therapy (ART) are known as elite controllers (ECs). ECs represent a heterogeneous population in terms of virological, immunological, and clinical outcomes, and approximately 25% of ECs lose viral control overtime. The studyofthemechanismsleadingtothelossofviralcontrol in ECs is crucial for the identification of differential mark- ers for the design of novel eradication and immunothera- peutic strategies.