Inter-areal synchronization of neuronal oscillations at frequencies below ~100?Hz is a pervasive feature of neuronal activity and is?thought to regulate communication in neuronal circuits. In contrast, faster activities and oscillations have been considered to be largely local-circuit-level phenomena without large-scale synchronization between brain regions. We show, using human intracerebral recordings, that 100–400?Hz high-frequency oscillations (HFOs) may be synchronized between widely distributed brain regions. HFO synchronization expresses individual frequency peaks and exhibits reliable connectivity patterns that show stable community structuring. HFO synchronization is also characterized by a laminar profile opposite to that of lower frequencies. Importantly, HFO synchronization is both transiently enhanced and suppressed in separate frequency bands during a response-inhibition task. These findings show that HFO synchronization constitutes a functionally significant form of neuronal spike-timing relationships in brain activity and thus a mesoscopic indication of neuronal communication per se. High-frequency oscillations (HFOs) are common in mammalian brains and have been assumed to be strictly local. Using human intracerebral recordings, the authors find that HFOs can be phase synchronized across long distances between active cortical sites during resting and task states, which may reflect neuronal communication.
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