Transgelin (TAGLN) Regulates IQGAP1 and Alters the Functions of Breast Cancer Cells

摘要

Several studies have been conducted on the transgelin (TAGLN) protein and its critical role in cancer biology. However, the regulation of this protein and the way in which this regulation is correlated with the functions of IQ motif‐containing GTPase‐activating protein 1 (IQGAP1) in MDA‐MB231 cells, remain unclear. We generated stable TAGLN‐knockdown and TAGLN‐overexpressing cells. These cells, along with their control counterparts, were cultured in the presence or absence of 17‐AAG. The different cell groups were then subjected to functional assays to assess proliferation, chemotaxis, and invasion. TAGLN regulation was found to affect the efficacy of 17‐AAG. The ability of TAGLN to influence the levels of IQGAP1 and its binding partners altered the critical functions of breast cancer cells. Therefore, the altered functionality of MDA‐MB‐231 cells, as a consequence of TAGLN regulation, is correlated with IQGAP1 signaling.