Background Congenital heart defect (CHD) is the most common major malformations in infants. Little is known about the main epidemiologic characteristics of CHD prevalence in Guangdong province, China. Our study was undertaken to investigate the time trends in the prevalence of CHD in Guangdong province from 2008 to 2012. Methods Data were retrieved from the Guangdong Hospital-Based Birth Defects Monitoring System during 2008–2012. All infants more than 28?weeks of gestation and infants up to 7?days of age in monitoring hospitals were monitored. We used prevalence rate to describe the difference in prevalence of CHD between rural and urban areas. Odds ratio (OR) and 95% confidence interval (CI) for CHD were calculated for the rural and urban areas. The CHD rate was calculated on the basis of birth defects per 10,000 births. Results A total of 1005052 births were reported to the Birth Defects Monitoring Network of Guangdong Province, of which 5268 cases were diagnosed as CHD. The overall prevalence of CHD was 52.41 per 10 000 births (95% CI: 51.00?~?53.83) in provincial-wide, 66.08 per 10 000 births (95% CI: 63.77?~?68.39) in urban areas, and 40.23 per 10 000 births (95% CI: 38.52?~?41.93) in rural areas. The prevalence of CHD increased with maternal age both in urban areas (P?P? Conclusion The increasing trends of CHD prevalence suggest that maternal age and the improvement of diagnosis ability might play a critical role.
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