Pharmacological mechanisms of Yishen Xingyang capsule in the treatment of oligoasthenospermia in rats

摘要

ObjectiveTo investigate the therapeutic effects and pharmacological mechanisms of Yishen Xingyang capsule (YXC) in oligoasthenospermia (OA) rats.MethodsForty-eight male Sprague–Dawley rats were randomly divided into eight groups of six rats each: normal control (NC); model control (MC); three different positive drug (PD); and low-, medium-, and high-dose YXC groups. A rat model of OA was established by administering glucosides ofTripterygium wilfordiiHook. F (GTW). After YXC administration, penile erectile function was observed. The epididymis, blood, and testes of the rats were harvested for analysis of sperm quality, sex hormone levels, mitochondrial membrane potential, and the transforming growth factor (TGF)-β1/Smad signaling pathway.ResultsCompared with that in the MC group, penile erectile function in the YXC groups and three PD groups increased (allP?