Which one, gastric parietal cell antibody positivity or hyperhomocysteinemia, is a better biomarker to predict oral mucosal disease patients with vitamin B12 deficiency?

摘要

The gastric parietal cell antibody (GPCA) is an autoantibody that can destroy gastric parietal cells, resulting in lack of intrinsic factors. 1e3 Intrinsic factor deficiency may lead to malabsorption of vitamin B12 from terminal ileum and finally the vitamin B12 deficiency. 1e5 However, other con- ditions including inadequate intake, food-bound vitamin B12 malabsorption, the presence of intrinsic factor anti- body in sera of patients, ileal malabsorption in patients with enteritis or ileal resection, biologic competition including bacterial overgrowth and tapeworm infestation, and defective transport such as transcobalamin II defi- ciency may also cause the vitamin B12 deficiency.