Background: The objective of this review is to elucidate the principles of complete denture aesthetics and establish a rationale for a digital workflow for chairside arrangement of artificial teeth. Types of studies reviewed: Articles were culled on the topic of complete denture aesthetics and the digital fabrication of complete dentures. These included systematic and literature review articles as well as clinical, descriptive and in vitro studies that range from 1958 to 2020 using PubMed and Web of Science databases. Results: Biometric measurements have been illuminated over the last 60 years, serving as a basis for analogue and digital denture aesthetics. However, a number of studies have shown that individual arrangement of the anterior teeth is essential to capture asymmetry and balance in the setup. This review highlights that customization of the smile is optimally done chairside with patient feedback. A proof of concept was identified from the literature to incorporate a wax try-in in the digital workflow. Practical implications: Given the heightened value placed on aesthetics in dentistry, a review of complete denture aesthetics will enhance the clinician’s skillset, and incorporating a chairside try-in in the digital workflow will lead to more authentic prostheses.
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