Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1–FOXO1/3–PINK1–Parkin-mediated mitophagy

摘要

Highlights?Physical exercise efficiently prevents the progression of Alzheimer's disease and mitigates the risk of developing the disease.?Physical exercise acts against the development and progression of Alzheimer's disease via promoting mitochondrial fitness.?Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin–mediated mitophagy.