Hybrid chiller plants (HCPs) using multiple chillers and different energy sources are highly recommended in several energy applications in non-residential buildings such as hospitals and hotels. Time of use and cooling load profiles are significant factors that should be carefully considered either in chiller plant design or in chiller sequencing operation. This article aims to present an operation planning of HCP which consists of both electric and non-electric chillers. Four operational strategies are proposed and solved to compare their coefficients of performance and economics of running costs. A typical hotel building located on the Nile river in Egypt is selected to perform the current thermal and economic case study. The total cooling load profile of this hotel building is 4000 refrigeration tonnage (TR), which is simulated to optimize chiller sequence of operation and to select optimal design conditions of both numbers for electric and non-electric chillers used in HCP. The results of this comparative study for running cost are defined using various design configurations with different several chiller sequences available for each configuration. Then, the results of COPs, and operational running cost and initial cost are presented in this article also. The comparison aims to find the optimal design and operational sequencing for HCPs on thermal basis and economic analysis which were attached in this article. Recommendations and suggestions for future work are attached at the end of this article.
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