Background: Chronic Suppurative Otitis Media (CSOM) is a one of the major public-health problems and presenting with high prevalence rate in developing countries like India. Necessity to immediate intervention and treatment is required as the persistent infection is associated with increased risk of extracranial and intracranial complications. Aim and Objectives: This study was undertaken to determine the microbial profile of CSOM and also to detect the resistance pattern of bacterial pathogen isolated. Material and Methods: This prospective analytical single centre study was done on patients presenting with ear discharge of more than 6 weeks duration. All the samples were processed for aerobic bacterial and fungal culture and antibiotic susceptibility testing was done by Kirby Bauer Disc Diffusion Method. Results: Analysis of 85 pus samples from CSOM showed 97.6% were culture positive and 2.3% were culture negative. Of 83 culture positive samples, 79 (95.2%) were monomicrobial and 4 (4.8%) were polymicrobial. The predominant organisms isolated from CSOM was Pseudomonas spp (52.9%), followed by Staphylococcus aureus (20.7%). Antimicrobial sensitivity testing showed that 10.7% of Gram negative bacilli were Extended Spectrum Beta-Lactamase (ESBL) producers and 16.6% of Staphylococcus aureus was Methicillin resistant and 33.7% of the 86 isolates were resistant to Ciprofloxacin. Conclusion: In conclusion, our study on microbial profile of CSOM showed Pseudomonas aeruginosa was predominantly isolated followed by Staphylococcus aureus and around 45% of the isolates were resistant to Ciprofloxacin. Knowledge on the predominant isolates and their antibiotic susceptibility pattern of the bacteria isolated from CSOM is very crucial for starting the empirical treatment, prior to availability of susceptibility reports from the laboratory.
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