BACKGROUND:Most patients including health care workers (HCWs) survived the coronavirus disease 2019 (COVID-19), however, knowledge about the sequelae of COVID-19 after discharge remains limited.METHODS:A prospectively observational 3-month follow-up study evaluated symptoms, dynamic changes of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) IgG and IgM, lung function, and high resolution computed tomography (HRCT) of survivors of COVID-19 after discharge at Wuhan Union Hospital, China.RESULTS:Seventy-six survivors (55 females) with a mean age of 41.3 ± 13.8 years were enrolled, and 65 (86%) were HCWs. A total of 69 (91%) patients had returned to their original work at 3-months after discharge. Most of the survivors had symptoms including fever, sputum production, fatigue, diarrhea, dyspnea, cough, chest tightness on exertion and palpitations in the three months after discharge. The serum troponin-I levels during the acute illness showed high correlation with the symptom of fatigue after hospital discharge (r = 0.782; P = 0.008) and lymphopenia was correlated with the symptoms of chest tightness and palpitations on exertion of patients after hospital discharge (r = -.285, P = 0.027; r = -.363, P = 0.004, respectively). The mean values of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC, total lung capacity and diffusion capacity were all normal ( 80% predicted) and lung HRCTs returned to normal in most of the patients (82%), however, 42% of survivors had mild pulmonary function abnormalities at 3-months after discharge. SARS-CoV-2 IgG turned negative in 11% (6 of 57 patients), 8% (4 of 52 patients) and 13% (7 of 55 patients), and SARS-CoV-2 IgM turned negative in 72% (41 of 57 patients), 85% (44 of 52 patients) and 87% (48 of 55 patients) at 1-month, 2-months and 3-months after discharge, respectively.CONCLUSION:Infection by SARS-CoV-2 caused some mild impairments of survivors within the first three months of their discharge and the duration of SARS-CoV-2 antibody was limited, which indicates the necessity of long-term follow-up of survivors of COVID-19.? 2020 The Korean Academy of Medical Sciences.
展开▼
机译：背景：大多数患者包括医疗保健工作者（HCWS）在冠状病毒疾病（Covid-19）中幸存下来，但是，在出院后的Covid-19后遗症的知识仍然有限公司。方法：评估前瞻性观察到3个月的后续研究武汉联盟医院武汉市武汉市武汉市区留下急性呼吸综合征 - 冠状病毒-2（SARS-COV-2）IgG和IgM，肺功能和高分辨率计算断层扫描（HRCT）的症状，动态变化。结果：七十六名幸存者（55名女性），均为41.3±13.8岁的平均年龄，65（86％）是HCW。总共69名（91％）患者在出院后3个月返回原实项。大多数幸存者有症状，包括发烧，痰液生产，疲劳，腹泻，呼吸困难，咳嗽，胸部紧绷，在放电三个月后的三个月内的劳累和心悸。急性疾病期间的血清肌钙蛋白-I水平与医院排放后疲劳症状的症状（R = 0.782; p = 0.008）和淋巴细胞症与胸闷和心悸的症状相关，在医院排放后患者（ r = -.285，p = 0.027; r = -.363，p = 0.004分别）。强制呼气量在1秒（FEV1），强制生命能力（FVC），FEV1 / FVC，总肺容量和扩散能力中的平均值都是正常的（> 80％预测），肺部HRCT在大多数情况下恢复正常然而，患者（82％），42％的幸存者在出院后3个月在3个月内具有温和的肺功能异常。 SARS-COV-2 IgG在11％（57名患者中的6个中的6个），8％（52名患者中的4个）和13％（55名患者中的7个），SARS-COV-2 IgM在72％中逆为阴性（41个57名患者），85％（44名患者中的44名，共52例）和87％（55名患者中的48名患者中的48名患者中48名）分别放电后2个月和3个月。结论：SARS-COV-2感染导致一些在其排放后的前三个月内的幸存者和SARS-COV-2抗体的持续时间有限的温和损伤，这表明了Covid-19幸存者的长期随访的必要性。？ 2020韩国医学科学院。
展开▼
