Background/purposeOral lichen planus (OLP) is a localized autoimmune oral mucosal disease. This study evaluated whether different types of OLP patients including erosive OLP (EOLP), major EOLP, minor EOLP, and non-erosive OLP (NEOLP) patients had significantly higher percentages of FoxP3+CD4+or IFN-γ+CD4+cells in total CD4+cells, and of IFN-γ+CD8+cells in total CD8+cells than healthy control subjects and whether the patient's age had significant influences on these cell percentages in OLP patients.Materials and methodsFlow cytometry was used to count the FoxP3+CD4+, IFN-γ+CD4+, or IFN-γ+CD8+cell levels in 183 OLP patients (67 major EOLP, 81 minor EOLP, and 35 NEOLP patients) and 20 healthy control subjects.ResultsMajor EOLP patients had a significantly higher FoxP3+CD4+cell percentage than health control subjects (P?=?0.049) or minor EOLP patients (P?=?0.008). Major EOLP patients had a significantly higher IFN-γ+CD4+or IFN-γ+CD8+cell percentage than healthy control subjects, NEOLP patients, or minor EOLP patients (allP-values?
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