Objective: A common problem in clinical laboratories is maintaining the stability ofanalytes during pre-analytical processes. The aim of this study was to systematicallysummarize the results of a set of studies about the biochemical analytes stability.Methods: A literature search was performed on the Advanced search field of PubMedusing the keywords: “(stability) AND (analytes OR laboratory analytes OR laboratory tests OR biochemical analytes OR biochemical tests OR biochemical laboratorytests).” A total of 56 entries were obtained. After applying the selection criteria, 20articles were included in the study.Results: In the 20 included references, up to 123 different analytes were assessed.The 34 analytes in order of the most frequently studied analytes were evaluated:Alanine aminotransferase, aspartate aminotransferase, potassium, triglyceride, alkaline phosphatase, creatinine, total cholesterol, albumin, lactate dehydrogenase, sodium, calcium, γ-glutamyltransferase, total bilirubin, urea, creatine kinase, inorganicphosphate, total protein, uric acid, amylase, chloride, high-density lipoprotein, magnesium, glucose, C-reactive protein, bicarbonate, ferritin, iron, lipase, transferrin, cobalamin, cortisol, folate, free thyroxine, and thyroid-stimulating hormone. Stable testresults could be varied between 2 hours and 1 week according to the type of samplesand/or type of blood collection tubes on a basic classification set as refrigerated orroom temperature.Conclusions: Biochemical analytes stability could be improved if the best pre-analytical approaches are used.
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