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Diagnostic Value of Different Biomarkers to Identify Bacterial Coinfection in Vietnamese Children with Severe Rhinovirus Pneumonia

机译:不同生物标志物鉴定严重鼻病毒肺炎越南儿童细菌繁殖的诊断价值

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Abstract This study aims to assess the diagnostic value of high-sensitivity C-reactive protein (hs-CRP), procalcitonin (PCT), and interleukin (IL)-6 in the diagnosis of pneumonia caused by Rhinovirus alone or with bacterial coinfection in Vietnamese children under 5 years of age. A cross-sectional study was conducted on 26 children under 5 years of age with severe pneumonia due to Rhinovirus at the National Pediatric Hospital. IL-6, hs-CRP, and PCT tests were performed. The diagnostic values of PCT, IL-6, and hs-CRP in classifying those with viral alone and those with bacterial coinfection were determined. Of 26 children, 10 children were diagnosed to have bacterial coinfections (38.5%). The optimal cutoff point for PCT was??2.30 ng/mL (sensitivity 50%, specificity 94%, positive predictive value 83%, and negative predictive value 75%). The optimal cutoff point for hs-CRP was??1.53?mg/dl (sensitivity 90%, specificity 56%, positive predictive value 56%, and negative predictive value 90%). Finally, the optimal cut-off point for IL-6 was??441.5 pg/mL (sensitivity 20%, specificity 100%, positive predictive value 100%, and negative predictive value 60%). The accuracy rate of PCT was the highest with 69.2%, followed by hs-CRP with 65.4%. Inflammatory biomarkers such as PCT and hs-CRP were able to distinguish children with severe pneumonia caused by Rhinovirus alone and those with bacterial coinfection.
机译:摘要本研究旨在评估高敏感性C-反应蛋白(HS-CRP),ProCalcitonin(PCT)和白细胞介素(IL)-6在鼻咽血病诊断中的诊断价值或越南病毒的细菌繁殖5岁以下的儿童。由于国家儿科医院的rhinovirus,在5岁以下的26例儿童上进行了横断面研究。进行IL-6,HS-CRP和PCT测试。确定PCT,IL-6和HS-CRP在分类中的诊断值单独分类有病毒和具有细菌杂卷的人。 26例儿童,10名儿童被诊断出细菌繁殖(38.5%)。 PCT的最佳截止点是α>?2.30ng / ml(灵敏度50%,特异性94%,阳性预测值83%和负预测值75%)。 HS-CRP的最佳截止点?>?1.53?Mg / DL(灵敏度90%,特异性56%,阳性预测值56%和负预测值90%)。最后,IL-6的最佳截止点是?>αε?441.5 pg / ml(敏感性20%,特异性100%,阳性预测值100%,以及负预测值60%)。 PCT的精度率最高,69.2%,其次是HS-CRP,65.4%。 PCT和HS-CRP等炎症生物标志物能够区分鼻病毒单独引起的严重肺炎的儿童以及细菌繁殖。

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