The relationship of serum calprotectin with disease activity, functional status, ultrasonographic findings and radiological damage in rheumatoid arthritis patients

摘要

Aim of the workTo measure the levels of serum calprotectin (CLP) in rheumatoid arthritis (RA) patients and to assess its association with disease activity, functional status, ultrasonographic findings, and radiological damage.Patients and methodsThis study included 47 RA patients and 33 controls. The erythrocyte sedimentation rate (ESR), anti-cyclic citrullinated peptide (anti-CCP), rheumatoid factor (RF), C-reactive protein (CRP), disease activity score (DAS28), health assessment questionnaire (HAQ), modified Larsen radiological score, musculoskeletal ultrasound and serum CLP levels were assessed.ResultsThe mean age of the patients was 42.5?±?12.8?years; 34 females and 13 males (F:M 2.6:1) with a mean disease duration of 2.6?±?1.1?years. RF was positive in 72%. CLP level was significantly increased in patients compared to control (2.78?±?0.89?μg/ml vs. 0.84?±?0.5?μg/ml; p?