BackgroundInfection is a leading cause of morbidity, mortality and hospital admission in systemic lupus erythematosus (SLE) patients.Aim of the workTo study infection in SLE patients regarding site of infection, pathogenic organism, hospitalization and/or intensive care unit (ICU) admission.Patients and methodsThis study included 79 patients. SLE disease activity index (SLEDAI-2K) and damage index were evaluated. Detailed information about the site of infection and pathogens were reported.Results71 females and 8 male patients (F:M 8.9:1), with a mean age of 29?±?9.6?years (17–55?years) and disease duration of 5.9?±?5.7?years, 55 (69.6%) patients had infection at time of study while 24 (30.4%) did not. The SLEDAI-2?k and damage index were significantly higher in SLE patients with infection (14.2?±?11.8 and 3.7?±?3.7) compared to those without infection (5.9?±?5.03 and 1.8?±?1.3) (p?=?0.03 and p?=?0.045 respectively). Those with infection had a shorter disease duration (4.9?±?5.2vs8.3?±?6.2; p?=?0.005), received more cyclophosphamide (56.4%vs16.7%; p?=?0.001), higher erythrocyte sedimentation rate (ESR) (75.5?±?27.1vs35.8?±?24.7?mm/1sthr) (p?
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机译：BackgroundInfection是发病率，死亡率和住院系统性红斑狼疮（SLE）的主要原因的workTo研究感染的SLE患者有关的感染，病原生物，住院治疗和/或重症监护病房（ICU）录取现场的patients.Aim。病人和methodsThis研究纳入79个例。 SLE疾病活动性指数（SLEDAI-2K）和损伤指数进行了评价。关于感染和病原体的网站的详细信息是reported.Results71名女性和8名男性患者（F：M 8.9：1），与29±9.6岁（17-55年？），平均年龄和病程？？？ 5.9？±？5.7？年，55（69.6％）患者在研究的时候有感染，而24（30.4％）没有。所述SLEDAI-2？k和损伤指数在SLE患者显著高于感染（14.2？±？11.8和3.7？±？3.7）相比那些没有感染（5.9？±？5.03和1.8？±？1.3）（对？=？0.03和p分别？=？0.045）。那些与感染有一个较短的病程（4.9±5.2vs8.3±6.2;？？？？P = 0.005？），接收到的更环磷酰胺（56.4％vs16.7％; P = 0.001），较高的红细胞沉降率（ESR）（？？？？？75.5±27.1vs35.8±24.7毫米/ 1sthr）（？p <0.0001）和补体消耗（C3）（71.1±28.4vs97.2±28.2;？？2 p <？？0.0001）。 55分之17（30.9％）有感染的多个站点和46/55（83.6％）需要住院。住院患者的17（30.9％）被转移到ICU。主要致病生物体是细菌（40％），真菌（27.3％），病毒（10.9％）和在21.8％未确认。胸部其次是皮肤（34.4％），口咽（25.5％）和泌尿道（20％）最常见的网站（40％）。ConclusionInfection是医院和ICU住院的SLE患者的一个重要原因。早期疾病，疾病的活性和损坏，环磷酰胺，ESR和消耗C3用感染SLE相关联。
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