Clinical significance of serum survivin in rheumatoid arthritis patients: Relation to disease activity, functional status and radiological damage

摘要

Aim of the workTo measure the levels of serum survivin in rheumatoid arthritis (RA) patients and to assess its relation to disease activity, functional impairment, and radiological damage.Patients and methodsThis study included 58 RA patients and 34 controls. The erythrocyte sedimentation rate (ESR), anti-cyclic citrullinated peptide (anti-CCP), rheumatoid factor (RF), C-reactive protein (CRP), disease activity score 28 (DAS28), health assessment questionnaire score (HAQ), modified Larsen radiological score and serum survivin level were assessed.ResultsThe mean age of the patients was 43.5?±?11.5?years; 43 females and 15 males (F:M 2.9:1) with a mean disease duration of 2.6?±?1.13?years. RF was positive in 79% Survivin level was significantly increased in patients compared to the controls (171.8?±?74.4?pg/ml vs. 98.7?±?16?pg/ml, p?