Comment on: Diagnostic value of miR-186-5p for carotid artery stenosis and its predictive significance for future cerebral ischemic event

摘要

I read the article by Lv et al. published in Diagn Pathol 2020. They aimed to investigate the diagnostic value of miR-186-5p for asymptomatic carotid artery stenosis (CAS), and its predictive value for future cerebral ischemic events (CIEs) [1]. Sixty-seven cases with asymptomatic CAS and 60 healthy individuals were recruited. Receiving-operator characteristic (ROC) curve was drawn based on sensitivity and specificity analyses. Kaplan-Meier method was applied for the evaluation of the predictive value of miR-186-5p for the occurrence of CIE. They reported that area under the curve (AUC) was 0.91, with the sensitivity of 89.6% and specificity of 81.7% at the cutoff value of 1.22. Kaplan-Meier method results revealed that high miR-186-5p level was associated with the occurrence of CIEs.