Epidermodysplasia verruciformis: report of two patientswith autosomal dominant inheritance

摘要

Epidermodysplasia verruciformis is a raregenodermatosis associated with mutations in theEVER1/TMC6 and EVER2/TMC8 genes. The inheritanceis considered to be autosomal recessive, but reportssuggesting an autosomal dominant inheritanceindicate disease genetic heterogeneity. Its onsetoccurs in early childhood and presents as acombination of pityriasis versicolor-like, flat wart-likeand seborrheic keratosis-like lesions, with a potentialfor malignant transformation, mainly squamous cellcarcinoma.