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Clinical evaluation of infantile hemangiomas treated withatenolol

机译:婴儿血管瘤用丙醇处理的临床评价

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Currently, propranolol, is the first line treatment forproblematicinfantilehemangioma(IH) management. However, serious side effects have been reported.For that reason, atenolol, ahydrophilicselectivebeta-1blocker with the potential for fewer side effects, has been explored. A descriptive, observational case series study of 30 patients between the ages one to 5 months with superficial, deep, or mixed IH was conducted between January 2016 and December 2017. Oral atenolol was administered using a single once daily dose of 1mg/kg, which was adjusted for weight gain each month. The IH was assessed usingthe Hemangioma Activity Score (HAS) at initiation of treatment, four months, and 9 months of age and improvement percentage was calculated at four and nine months of age. A total of 25 patients completed three evaluations. The baseline, four-month, and 9 month HAS were 4.6, 2.39, and 0.65, respectively. Mean improvement percentage at four months of age was 46.76% and at 9 months of age was 85.65%. NO side effects were reported. This study suggests atenolol as an effective treatment for IH in almost all cases, especially in patients who initiated treatment before three months of age. It was well tolerated in all our cases.
机译:目前,ProPranolol,是第一线治疗ForproberaticInfantilehemangioma(IH)管理。然而,已经报道了严重的副作用。这是探讨了Atenolol,AyholophilicsElecectiveBeta-1Blocker,其潜在的副作用较少效应。描述性的,观察案例系列在2016年1月至2017年1月至2017年1月之间进行了一岁至5个月之间的30名患者。使用单一的每日剂量为1mg / kg,施用口服阿替洛尔。调整每月重量增长。在治疗开始时使用血管瘤活性分数(具有)评估IH,4个月和9个月的年龄,在四个和九个月内计算出来的改善百分比。共有25名患者完成了三个评估。基线,四个月和9个月分别为4.6,2.39和0.65。 5个月的平均改善百分比为46.76%,9个月的年龄为85.65%。没有报道任何副作用。本研究表明Atenolol在几乎所有病例中为IH的有效治疗,特别是在三个月前发起治疗的患者。在我们的所有案件中,它是良好的耐受性。

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