Erosive pustular dermatosis of the scalp induced by gefitinib:case and review of the literature

摘要

Gefitinib is a selective tyrosine kinase inhibitor ofepidermal growth factor receptor (EGFR) used for thetreatment of malignant neoplasms. The mostfrequent skin complication during gefitinib therapy isan acneiform papulopustular eruption, usuallydistributed in the seborrheic areas but occasionallywidespread. We report a patient with erosivepustular dermatosis of the scalp, a neutrophilmediated skin disease presenting with sterilepustules evolving into erosions and crusts on thescalp, during treatment with the EGFR inhibitorgefitinib for lung cancer. A literature review of thedrug-induced cases of this rare entity is provided.