...
首页> 外文期刊>Database >miR-TV: an interactive microRNA Target Viewer for microRNA and target gene expression interrogation for human cancer studies
【24h】

miR-TV: an interactive microRNA Target Viewer for microRNA and target gene expression interrogation for human cancer studies

机译:MIR-TV:用于MicroRNA的交互式microRNA目标观众和人类癌症研究的靶基因表达询问

获取原文
           

摘要

MicroRNAs (miRNAs) have been identified in many organisms, and they are essential for gene expression regulation in many critical cellular processes. The expression levels of these genes and miRNAs are closely associated with the progression of diseases such as cancers. Furthermore, survival analysis is a significant indicator for evaluating the criticality of these cellular processes in cancer progression. We established a web tool, miRNA Target Viewer (miR-TV), which integrates 5p-arm and 3p-arm miRNA expression profiles, mRNA target gene expression levels in healthy and cancer populations, and clinical data of cancer patients and their survival information. The developed miR-TV obtained miRNA-seq, mRNA-seq and clinical data from the Cancer Genome Atlas and potential miRNA target gene predictions from miRDB, targetScan and miRanda. The data presentation was implemented using the D3 javascript toolkit. The D3 toolkit is frequently used to provide an easy-to-use interactive interface. Our miR-TV provides a user-friendly and interactive interface, which can be beneficial for biomedical researchers to freely interrogate miRNA expression information and their potential target genes. We believe that such a data visualization bioinformatics tool is excellent for obtaining information from massive biological data.Database URL: http://mirtv.ibms.sinica.edu.tw
机译:在许多生物体中已经鉴定了MicroRNA(miRNA),并且它们对于许多临界细胞过程中的基因表达调节至关重要。这些基因和miRNA的表达水平与癌症如癌症的进展密切相关。此外,存活分析是评估这些细胞过程中癌症进展中这些细胞过程的关键性的重要指标。我们建立了一个Web工具,MiRNA目标查看器(MiR-TV),它集成了5p-ARM和3P-ARM miRNA表达型材,MRNA靶基因表达水平的健康和癌症群体,以及癌症患者的临床数据及其生存信息。发达的MIR-TV获得MiRNA-SEQ,MRNA-SEQ和来自癌症基因组地图集的临床资料,以及来自MIRDB,TARGETSCAN和MIRANDA的潜在miRNA靶基因预测。数据呈现是使用D3 JavaScript Toolkit实现的。 D3工具包通常用于提供易于使用的交互式界面。我们的MIR-TV提供了一种用户友好且互动的界面,这对生物医学研究人员可以自由地询问MiroNA表达信息及其潜在的靶基因。我们认为这种数据可视化生物信息化工具非常适合从大规模生物数据库获取信息.Database网址:http://mirtv.ibms.sinica.edu.tw

著录项

获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号