MCQs with Answers of October Issue 2019

摘要

What methodology is adopted for first-tier newborn screening test of measuring 17-hydroxyprogesterone (17- OHP) levels in dried blood spots in Hong Kong? a. High performance liquid chromatography b. Inductively coupled plasma mass spectrometry c. Gas chromatography with flame ionization detector d. Next generation sequencing e. Immunoassay 2. Which of the following is NOT associated with elevated 17-hydroxyprogesterone (17-OHP) levels in newborn? a. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency b. Low birth weight c. Prematurity d. Congenital adrenal hyperplasia due to 11 betahydroxylase deficiency e. Antenatal use of exogenous corticosteroid to enhance fetal lung maturation 3. First-t ie r sc r ee ning test o f me asur ing 1 7- hydroxyprogesterone (17-OHP) levels in dried blood spots suffers from poor specificity. Which of the following strategies can BEST improve the positive predictive value of congenital adrenal hyperplasia screening? a. Second-tier test by steroid profiling using liquid chromatography-tandem mass spectrometry (LC-MS/ MS) b. Ensure adequate feed before blood taking c. Blood taking in the morning d. Improvement in analytical specificity of antibodies employed in immunoassay e. Lower the screening cutoff values for 17-OHP.