By utilizing the oxidation of sodium bromide under acidic conditions, bromine is generated immediately, and a bromination reaction occurs with m-chlorophenylacetone. After amination, the salt is prepared to obtain bupropion hydrochloride. At the same time of synthesizing and preparing drugs, the shortcomings of the original aralkyl ketone bromination reaction are overcome, the danger of using bromine is eliminated, and the utilization rate of bromine element is greatly improved. And the recovery process of bromine element after the reaction is designed, and the closed-loop circulation of bromine is realized in the whole preparation process. The improved preparation process with a yield 78.5%, which eliminates the pollution of bromine, reduces the consumption of raw materials, realizes the clean production of medicines, and has higher application value.
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