Cancer-related fatigue is the most prevalent and persistently symptom in cancer survivors than any other symptom, which is caused by both the disease and its treatment. Patients with cancer show a severe symptom of fatigue, which cannot be relieved by general rest or sleep. Cancer-related fatigue negatively impacts a patient's physical andemotional function, social ability and even patients’ prognosis. At present, the mechanism of cancer-related fatigueremain unclear despite much research, and a variety of mechanisms may contribute to its occurrence anddevelopment, including inflammatory reaction, metabolism dysregulation, immune activation, hormonal changes, central nervous system dysfunction, etc. Now a broad variety of drugs and non-drugs interventions are used againstcancer-related fatigue. The intervention of conventional western medicine mainly contains hematopoieticstimulants, hormones, mental stimulants, and antidepressants, but their widely clinical application is limited bytheir effectiveness and possible side effects to a certain degree. There are also many forms of non-druginterventions for managing cancer-related fatigue, such as exercise intervention, psychological intervention, sleepintervention, nutrition intervention, bright white light therapy, etc. The aim of this review is to providerecommendations of non-drug interventions for patients with CRF during and after cancer treatment, in order toprovide an evidence-based guideline for clinicians.
展开▼
