Background: shoulder pain after laparoscopic procedure is a frequent complication encountered in surgery ward. Several treatments have been proposed to reduce it. This study aimed to evaluate the efficacy of preoperative administration of gabapentin in preventing and attenuating Post Laparoscpoic Shoulder Pain (PLSP) after laparoscopic cholecystectomy. Design: In a randomised, double blinded placebo controlled study. Setting: Woman's Hospital, Kermanshah University of Medical Sciences. Period: April 2011 to March 2012. Material and methods: 90 patients of ASA physical status I-II undergoing elective laparoscopic cholecystectomy were randomly allocated to receive gabapentin 600 mg or placebo ,half an hour before surgery. The presence analgesia and side effects were recorded for 12h postoperatively in same times. Results: Incidence Verbal Rating Scale (VRS) ≥ 4 at different times after arrival to PACU were significantly lower in gabapentin group in arrival (P Value= 0.003) and then after 30 miniute (P Value= 0.02) and 2 (P Value= 0.003), 4 (P Value= 0.03) and 6 (P Value= 0.04) hours after arrival to Post Anesthesia Care Unit (PACU). But this sigificancy lost at 12 hours (P Value= 0.07) after arrival to PACU. Also there was a reduction in amounts of postoperative in ward analgesic consumption. Side effects were not different between two groups. Conclusions: 600 mg gabapentin as premedication is effective and safe for reducing post-laparoscopic shoulder pain intensity after general laparoscopy compared with placebo
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