Objective: To calculate the prevalence of common types of cancer in SINDH based on Civil Hospital Karachi (CHK) database. Type of Study: Retrospective Observational Study. Place & Duration of Study: Clinical Oncology Department Civil Hospital Karachi, from January, 2004 to December 2011(8 Years). Methods: All the Patients attending the oncology department CHK were selected for study. After completing data the cancer registry patients were categorized according to their diagnosis and this data was recorded on Microsoft Excel sheet. Results: During period of January 2004 to December 2011, the total number of patients included in the study was 5504 out of which 2638 were males and 2866 females. The list of prevalence of different types of cancer was created and according to the statistical analysis based on CHK data base, the increasing trend was seen in breast, oral cavity, lymphoid tissue, blood, colorectal, liver & biliary tract, faciomaxillary, lung, uterus, esophagus, gastrointestinal stromal tumor, larynx, ovary, male genital system, Nasopharynx, urinary system and brain cancers. Conclusions: It is concluded that the registration of cancer patients is highly beneficial for the evaluation of cancer prevalence and incidence. This registration is also helpful for calculating the comparative incidence and prevalence of cancers on national and international levels. The recorded data will also help to improve the quality of life of cancer patients as this data is very much helpful to identify the etiology and risk factors of cancers which will improve health prevention and management plans by higher authorities
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