Cellular effects of extracellular purines were first reported in 1929 [1], which eventually gave rise to the concept of purinergic signalling, first proposed by Geoffrey Burnstock in 1972 [2]. The classification of P1 and P2 receptors followed later that decade [3], with the eventual sub-classification of P2 receptors into P2X and P2Y receptors in 1985 [4]. Since then, the field of purinergic signalling has grown to include ectonucleotidases [5], and ATP release channels and pathways [6]. This growth has coincided in part with the establishment of Purine Clubs with the first formalized in Italy in 1991 with subsequent clubs forming a decade later in Germany (2000), Japan (2003), Brazil (2009), the UK (2009) and North America (2009) [7]. The Chinese Purine Club was formed in 2018 and its inaugural meeting held in April 2019, Chengdu, China. The major activity of the various Purine Clubs has been their respective scientific meetings, with some involving combined club meetings such as the First Italian-German Club Meeting, Chieti, Italy (2005); the First United Kingdom-Italian Purine Club Meeting, Bristol, UK (2016); and First European Club Meeting, Santiago de Compostela, Spain (2019) [8].
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