Gallbladder cancers (GBCs) are highly malignant gastrointestinal cancers. The biological makers for the prognosis and targeting therapy of GBCs have not been established. The protein expression of Notch 1 and Notch 3 in 46 squamous cell/adenosquamous carcinomas (SC/ASCs) and 80 adenocarcinomas (AC) was measured using immunohistochemistry. Positive Notch 1 and Notch 3 expression in both SC/ASC and AC was significantly associated with large tumor size, invasion, metastasis, and low surgical curability (P??0.05 or P??0.01). Univariate Kaplan-Meier analysis showed that positive Notch 1 and Notch 3 expression was significantly associated with mean survival of SC/ASC and AC patients (P??0.01 or P??0.001). Multivariate Cox regression analysis showed that positive Notch 1 and Notch 3 expression, as well as low differentiation, large tumor size, high TNM stage, invasion, lymph node metastasis, and surgical curability are independent poor-prognostic factors in both SC/ASC and AC patients. Positive Notch 1 and Notch 3 expression is closely correlated with severe clinicopathological characteristics and poor prognosis in both SC/ASC and AC patients.
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机译:胆囊癌(GBCS)是高度恶性胃肠癌。尚未确定用于预后和GBC的靶向治疗的生物制造商。使用免疫组化测量46个鳞状细胞/腺癌癌(SC / ASC)和80个腺癌(AC)中的Notch1和Notch 3的蛋白质表达。 SC / ASC和AC中的阳性凹口1和Notch 3表达与大的肿瘤大小,侵袭,转移和低手术可固化有显着相关( P EM>?<?0.05或< EM Class =“Emphasistapitalic”> P Em>?<?0.01)。单变量Kaplan-Meier分析表明,阳性凹口1和缺口3表达与SC / ASC和AC患者的平均存活有显着相关( P EM>?<?0.01或 P Em>?<?0.001)。多变量Cox回归分析表明,阳性凹口1和Notch 3表达,以及低分化,大肿瘤大小,高TNM阶段,侵袭,淋巴结转移以及外科固化是SC / ASC和AC中的独立差的预后因素耐心。阳性缺口1和缺口3表达与SC / ASC和AC患者的严重临床病理特征和预后差密相关。
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