Background Neonatal mortality is one of the major public health problems throughout the world and most notably in developing countries. There exist inconclusive findings on the effect of antenatal care visits on neonatal death worldwide. Thus, the aim of this systematic review and meta-analysis was to reveal the pooled effect of antenatal care visits on neonatal death. Methods The present systematic review and meta-analysis was performed using published literature, which was accessed from national and international databases such as, Medline/PubMed, EMBASE, CINAHL, Cochrane Central library, Google Scholar, and HINARI. STATA/SE for windows version 13 software was used to calculate the pooled effect size with 95% confidence intervals (95% CI) of maternal antenatal care visits on neonatal death using the DerSimonian and Laird random effects meta-analysis (random effects model), and results were displayed using forest plot. Statistical heterogeneity was checked using the Cochran Q test (chi-squared statistic) and I 2 test statistic and by visual examination of the forest plot. Results A total of 18 studies, which fulfilled the inclusion criteria, were included in the present systematic review and meta-analysis. The finding of the present systematic review and meta-analysis revealed that antenatal care visits decrease the risk of neonatal mortality [pooled effect size 0.66 (95% CI, 0.54, 0.80)]. Cochrane Q test ( P 2 statistic revealed sizeable heterogeneity up to 80.5% ( I 2?=?80.5%). In the present meta-analysis traditional funnel plot, Egger’s weighted regression ( P =?0.48) as well as Begg’s rank correlation statistic ( P =?0.47) revealed no evidence of publication bias. Conclusions The present systematic review and meta-analysis revealed that antenatal care visits were significantly associated with lower rates of neonatal death. The risk of neonatal death was significantly reduced by 34% among newborns delivered from mothers who had antenatal care visits. Thus, visiting antenatal care clinics during pregnancy is strongly recommended especially in resource-limited settings like countries of sub-Saharan Africa.
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机译：背景技术新生儿死亡率是世界各地的主要公共卫生问题之一，最重要的是发展中国家。存在对全世界新生病死亡率的影响不确定的结果。因此，这种系统审查和荟萃分析的目的是揭示产前护理对新生儿死亡的合并效应。方法使用已发表的文献进行本系统审查和荟萃分析，该文献从国家和国际数据库中获取，如Medline / PubMed，Embase，Cinahl，Cochrane Central图书馆，Google Scholar和Hinari。 STATA / SE for Windows版本13软件用于计算使用·乳房和莱尔德随机效应Meta分析（随机效果模型）对新生儿死亡的95％置信区间（95％CI）的汇集效果大小（95％CI）。使用森林图显示结果。使用Cochran Q测试（Chi-Squared统计）和I 2测试统计以及森林图的视觉检查检查统计异质性。结果总共18项研究，该研究符合纳入标准，包括在本系统审查和荟萃分析中。目前的系统评论和荟萃分析的发现表明，产前护理评论降低新生儿死亡率的风险[合并效应大小0.66（95％CI，0.54,0.80）]。 Cochrane Q测试（P 2统计显示大量的异质性高达80.5％（I 2？= 80.5％）。在目前的荟萃分析传统的漏斗绘图中，Egger的加权回归（P = 0.48）以及Begg的等级相关统计（P = 0.47）没有显示出版物偏见的证据。结论目前的系统审查和荟萃分析表明，产前护理访问与新生儿死亡率的较低率显着相关。新生儿中新生病的风险明显减少了34％从有产前护理访问的母亲提供。因此，强烈建议在怀孕期间访问产前护理诊所，特别是在资源限制的环境中，如撒哈拉以南非洲国家。
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