Here, we would like to provide a short response to Letter to the Editor written by a respected human anatomists and histologists (Varga et al. 2020). The muscles of animals represent 40 to 50 % of their body weight, and the greatest part of this mass consists of cross-striated skeletal muscles (Makovicky et al. 2009d). At present it is a subject of intensive veterinary research, as muscles represent one of the most important elements in human nutrition. In addition, they are at the centre of applied research especially for muscular dystrophies, which are histologically characterized by muscular fiber atrophy, fragmentation and necrosis. Therefore, muscular fiber regeneration is an important part of research, but reparation is only the final stage of skeletal muscle damage. It seems that gene mutations play major roles in muscular dystrophies. On the other hand, it can also be expressed that myopathology in veterinary medicine is still lacking sufficient knowledge, but we are certain that future discoveries about individual gene mutations will change the view of skeletal muscle disease classification. Several studies have concentrated on the pathophysiology of muscular dystrophies, and muscular fiber splitting is interpreted here as a degenerative process. From this, several experimental studies documented muscular fiber splitting as a result of intensive exercise (Antonio and Gonyea 1994, Ho et al. 1980, Sola et al. 1973) or also exercise and nutrition (Eriksson et al. 2006).
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