Human coronary artery tree is a physiological transport system for oxygen and vital materials through a hierarchical vascular network to match the energy demands of myocardium, which has the highest oxygen extraction ratio among body organs and heavily depends on the blood flow for its energy supply. Therefore, it would be reasonable to expect that the key design principle of this arterial network is to minimize energy expenditure, which can be described by allometric scaling law. We enrolled patients who underwent coronary computed tomography angiography without obstructive lesion. The cumulative arterial length (L), volume (V), and diameter (D) in relation to the artery‐specific myocardial mass (M) were assessed. Flow rate (Q) was computed using quantitative flow ratio (QFR) measurement in patients who underwent invasive angiography. A total of 638 arteries from 43 patients (mean age 61?years, male gender 65%) were analyzed. A significant power‐law relationship was found among L–M, V–M, D–M, V–L, D–L, and V–D, and also among Q–M, Q–L, Q–V, and Q–D in 106 arteries interrogated with QFR (p??.001, all). Our results suggest that the fundamental design principle of the human coronary arterial network may follow allometric scaling law.
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