Begonia grandis Dryand (Family: Begoniaceae) was screened for its phytoconstituents and evaluated for its ethnomedicinal potential as an antioxidant and hepatoprotective agent. The preliminary phytochemical studies of the B. grandis revealed the presence of alkaloids, flavonoids, glycosides, triterpenoids, and steroids. Antioxidant effect of the methanolic extract was assessed by DPPH, superoxide, hydroxyl radical scavenging activity, and hepatoprotective effect by CCl 4 -induced hepatotoxicity. The extract showed significant antioxidant and hepatoprotective effects at a dose of 400 mg/kg similar to that observed in ascorbic acid and silymarin.
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机译:映上秋海棠Grandis Dration(家族:秋海棠)筛选其植物植物,并评估其作为抗氧化剂和肝保护剂的血统潜力。 B. Grandis的初步植物化学研究显示了生物碱,类黄酮,糖苷,三萜类化合物和类固醇的存在。通过DPPH,超氧化物,羟基自由基清除活性评估甲醇提取物的抗氧化效果,CCL 4-诱导的肝毒性,肝脏保护作用。该提取物在400mg / kg的剂量下显示出显着的抗氧化剂和肝脏保护作用,其类似于在抗坏血酸和甲硅烷林中观察到的剂量。
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