Amelioration of doxorubicin-induced cardiotoxicity by oral lyophilized Dunaliella salina supplement in a female wistar rat model with active estrous cycle and surgical menopause

摘要

Background: Whole-cellDunaliella salina iseffectivein preventing doxorubicin (DOX)-induced cardiotoxicity in female Wistar rats with surgicalmenopause. Materials andMethods: In ourexperiment, wesurgically induced menopausein a group ofWistar ratsand given doses ofDOXand/or D. salina lyophilized powderand compared itseffects with the group ofrats having a normalestrouscycle. Acumulative dose of 25 mg/kgBW ofDOXwas given to inducecardiotoxicity and wascountered by 1000 mg/kgBW ofD. salina oralsupplement or 10 mg/kgBW oftamoxifen. Totally two groups ofrats weresupplemented withD. salina , in one ofthe groups it was given eithera week before DOXinitiation,and in the other group, it was given alongside DOXdoses. Results: Theconcomitant D. salina supplement has been found to reducethecardiac damage dueto DOXbetter than the groups that received thesupplement beforehand DOXinitiation or tamoxifen. Besides, thesupplement wasalso found to maintain nitroso-redox balance, thus preventing cardiomyocyte death ascompared with therats that received DOXalone. It wasevident fromthe histopathologicalexamination and serumlevels ofcardiactroponin-T. Conclusion: Thus, oralcarotenoid supplementation can bea promising functionalfood over tamoxifen, whichwould help in recovering frommenopauseand preventanthracyclinecardiotoxicity.