Preoperative neoadjuvant chemotherapy on surgical condition and oncogene expression in advanced gastric cancer

摘要

Objective: To evaluate the effect of preoperative neoadjuvant chemotherapy regimen of XELOX(capecitabine combined with oxaliplatin) on surgical condition and oncogene expression in advancedgastric cancer.Methods: From January 2015 to July 2016, 124 patients with advanced gastric cancer who were admittedto our hospital were selected. Random number table method was used to divide them into an observationgroup and a control group, 62 each group. The observation group received two courses of neoadjuvantchemotherapy (XELOX) before operation, and the control group received surgery. The operation condition,expression of oncogenes in gastric cancer lesions, occurrence of adverse reactions and the long-termprognosis were compared between the two groups.Results: The R0 resection rate of the observation group was significantly higher than that of the controlgroup, and the difference was statistically significant (P0.05). The operation time of the observationgroup was shorter than that of the control group, the amount of intraoperative bleeding and the amountof postoperative drainage of the observation group were less than that of the control group, and thedifferences were statistically significant (P0.05). The mRNA expression of gastrokine 1, multiple tumorsuppressor protein, Wilms tumor gene on the X chromosome (WTX gene) and gene of phosphate andtension homology deleted on chromosome ten (PTEN gene) in the observation group after treatment wassignificantly higher than that in the control group before treatment, and the increase amplitude of theobservation group was more obvious than that of the control group (P0.05). There was no significantdifference in the incidence of adverse reactions between the two groups (P0.05). In terms of long-termprognosis, the disease-free survival time and average survival time of the observation group during thetwo-year follow-up period were significantly better than those of the control group, and the recurrencerate of the observation group was significantly lower than that of the control group; the differences werestatistically significant (P0.05).Conclusion: Preoperative XELOX for advanced gastric cancer patients can effectively increase the proportionof radical surgery, reduce the risk of surgery, and significantly regulate the expression of oncogene, thusimproving the long-term prognosis of patients.