Objective: Serum Vitamin-D plays pivotal role in inflammatory and infectious diseases; among them liverinfections are more distinct. This study was aimed to determine Vitamin-D status in HCV-infected patientsand healthy controls in Faisalabad, Pakistan.Methods: We performed randomized cross-sectional study of 74 individuals from 20th August, 2017 to20th February 2018 at The University of Faisalabad and Dar us Shifa Clinic, Faisalabad. Fifty-one patientswere hepatitis C RNA-PCR positive (22 compensated cirrhotic and 29 decompensated cirrhotic patients).In addition, 23 subjects without liver disease were recruited as healthy control. HCV RNA–PCR wasperformed by ARTUS ? HCV QS-RGQ V1. Vitamin-D levels were measured by chemiluminescence. SPSSversion 20 was used for statistical analysis.Results: The mean level of Vitamin-D was significantly lower in HCV patients in compensated anddecompensated cirrhotic patients (26.85 ng/mL & 20.65 ng/mL respectively) as compared to healthycontrols (30.41 ng/mL). This study showed sub optimal level of Vitamin-D in 76.5% of HCV patients.Vitamin-D insufficiency (21-29 ng/mL) as prevalent among healthy individuals (47.8%) as well as inHCV patients (39.2%) (P 0.001). In addition, Vitamin-D levels showed inverse relationship with moresevere conditions of liver disease as 55.2% of decompensated cirrhosis patients were sufferer ofVitamin-D deficiency as compared to 13.6% deficiency of Vitamin-D in compensated cirrhotic group(P 0.0001).Conclusion: Suboptimal levels of Vitamin-D (deficiency or insufficiency) are prevalent in patients havinghepatitis C infection as compared to healthy controls. Deficiency of Vitamin-D was directly associated withseverity of disease.
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