Objective: To observe the changes of lipid metabolism, blood glucose level and insulin sensitivity in patients with Type-2 diabetes after progressive weight loss of their body weight, so as to lay a theoretical foundation for diabetes treatment and education in the future. Methods: One hundred obese patients with Type-2 diabetes (BMI ≥ 25 kg/m2) who visited the endocrinology department of our hospital from April 2017 to April 2018 were given diabetes health education, diabetic diet, exercise and other measures to control their weight. The changes of blood glucose, blood lipid, insulin level and insulin release test before weight loss (T1), and at the time points of weight loss reached 5% (T2), 10% (T3) and 15% (T4) were recorded respectively to understand the influence of progressive weight loss on relevant indexes of patients. Results: With the decrease of body weight, the differences of TC, TG, LDL-C and HDL-C at different weight loss points were significant (p 0.05), and the changes of fasting blood glucose in 5% and 10% weight loss were significant (p = 0.02). The 2h postprandial blood glucose showed the most significant difference when the weight loss reached 15% (p = 0.00). There was no statistical difference in the change of glycosylated hemoglobin among different weight loss points (p = 0.08). When the weight loss reached 10%, the blood insulin level was significantly lower than that before the weight loss, while the insulin level was not significantly changed when the weight loss reached 15%, but the peak of secretion was shifted forward. It is suggested that insulin sensitivity gradually increases with weight loss. Conclusion: Obese patients with Type-2 diabetes can benefit from weight loss, with abnormal blood glucose and lipid metabolism improved, insulin resistance relieved, and insulin sensitivity increased. doi: https://doi.org/10.12669/pjms.36.7.3027 How to cite this:Kong DX, Xiao Y, Zhang Z, Liu Y. Study on the Correlation between Metabolism, Insulin Sensitivity and progressive weight loss change in Type-2?Diabetes. Pak J Med Sci. 2020;36(7):---------. doi: https://doi.org/10.12669/pjms.36.7.3027 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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机译：目的：观察2型糖尿病患者的脂质代谢，血糖水平和胰岛素敏感性的变化，逐渐减肥丧失其体重，为未来糖尿病治疗和教育的理论基础。方法：从2017年4月到2018年4月到2018年4月访问过型医院的2型糖尿病患者（BMI≥25kg/ m2）的患者被糖尿病健康教育，糖尿病饮食，运动等措施控制其体重。血糖，血脂，胰岛素水平和胰岛素释放试验的变化（T1），并且在重量损失的时间点达到5％（T2），记录了10％（T3）和15％（T4）分别了解逐步减肥对患者相关指标的影响。结果：随着体重的降低，TC，TG，LDL-C和HDL-C在不同体重减轻点的差异显着（P <0.05），以及5％和10％重量的空腹血糖的变化损失很大（P = 0.02）。当体重减轻达到15％时，2H后血糖显示出最显着的差异（p = 0.00）。不同重量损失点之间的糖基化血红蛋白的变化没有统计学差异（p = 0.08）。当体重减轻达到10％时，血液胰岛素水平显着低于重量损失，而当体重减轻达到15％时，胰岛素水平不会显着变化，但分泌的峰值向前移动。建议胰岛素敏感性随体重减轻逐渐增加。结论：2型糖尿病患者可以从体重减轻中受益，血糖异常和脂质代谢改善，胰岛素抗性缓解，胰岛素敏感性增加。 DOI：https://doi.org/10.12669/pjms.36.7.3027如何引用这个：kgen dx，小y，张z，刘Y.一种新陈代谢，胰岛素敏感性与逐渐减肥变化的相关性研究-2？糖尿病。 Pak J Med Sci。 2020; 36（7）：---------。 DOI：https://doi.org/10.12669/pjms.36.7.3027这是一个开放的访问文章，根据Creative Commons归因许可证（http://creativecommons.org/licenses/by/3.0）分发只要正确引用原始工作，允许在任何媒体中不受限制使用，分发和再现。
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