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外文期刊>Pan African Medical Journal
>Asthma co-morbidities in Nigerian children: prevalence, risk factors and association with disease severity and symptoms control
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Asthma co-morbidities in Nigerian children: prevalence, risk factors and association with disease severity and symptoms control
Introduction:Prompt recognition and management of co-morbidities is an important step in ensuring optimal childhood asthma symptoms control. This study sets out to determine the prevalence, predictive factors and association of co-morbidities with asthma severity, lung functions and symptoms control in Nigerian children.Methods:Children (aged 2 to 15 years) with physician-diagnosed asthma at the Wesley Guild Hospital, Nigeria were consecutively recruited. Asthma co-morbidities, severity and levels of symptoms control were assessed using standard definitions. Lung functions of children ≥ 6 years were also measured. Factors predictive of asthma co-morbidities and association of co-morbid conditions with asthma severity, lung functions and symptoms control were determined using univariate and multivariate analyses.Results:A total of 186 children (male: female 1.4:1) were recruited and the majority (81.0%) had mild intermittent asthma. Forty (21.5%) had suboptimal symptoms control and 112 (60.2%) had associated co-morbidities. Allergic rhinitis and/or conjunctivitis (41.4%) were the most common co-morbidities. Predictors of concomitant presence of allergic rhinitis among the children were older age group ≥ 6 years (OR = 2.488; 95%CI 1.250-4.954; p = 0.036) and lack of exclusive breastfeeding (OR = 2.688; 95%CI 1.199 -5.872; p = 0.020) while obesity/overweight (OR = 6.300; 95%CI 2.040-8.520; p = 0.003) and Allergic rhinitis (OR = 2.414; 95%CI 1.188-6.996; p = 0.049) were determinants of persistent asthma. Suboptimal symptoms control was associated with having concomitant allergic rhinitis (p = 0.018), however no comorbid condition predicted lung function impairment.Conclusion:About two-thirds of children with asthma had co-morbidities and allergic rhino-conjunctivitis was the most common. School age group and early introduction to breast milk substitutes predict the presence of these co-morbidities which also affect asthma severity and control.? Bankole Peter Kuti et al.
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机译：介绍：迅速识别和管理的共同生命是确保最佳儿童哮喘症状控制的重要一步。本研究阐述了尼日利亚儿童哮喘严重程度，肺功能和症状控制的患病率，预测因素和伴有哮喘症状和症状控制的患病率。方法：儿童（2至15岁）在Wesley公会医院的医生诊断，尼日利亚连续招募。使用标准定义评估哮喘共同病态，严重程度和症状控制水平。还测量了儿童肺功能≥6岁。使用单变量和多变量分析确定了哮喘严重程度，肺功能和症状对哮喘患者的哮喘持续性病态和患有哮喘症状的因素。结果：招募了186名儿童（男性：女性1.4：1）。大多数（81.0％）有轻度间歇性哮喘。四十（21.5％）的次优症状控制，112名（60.2％）有相关的共同状况。过敏性鼻炎和/或结膜炎（41.4％）是最常见的共同状况。儿童伴随过敏性鼻炎的预测因素≥6岁（或= 2.488; 95％CI 1.250-4.954; P = 0.036），缺乏独家母乳喂养（或= 2.688; 95％CI 1.199 -5.872; P = 0.020）而肥胖/超重（或= 6.300; 95％CI 2.040-8.520; P = 0.003）和过敏性鼻炎（或= 2.414; 95％CI 1.188-6.996; p = 0.049）是持续性哮喘的决定因素。次优症状控制与伴随的过敏性鼻炎有关（P = 0.018），无论是否没有共用病情预测肺功能损伤。结论：约有三分之二的哮喘儿童具有共同的rhino-unjigisitis是最常见的。学龄群组和早期母乳替代品预测这些同事的存在，这也影响哮喘严重程度和控制。 Bankole Peter Kuti等。
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