First Asian, Single‐Center Experience of Blastocyst Preimplantation Genetic Diagnosis with Human Leukocyte Antigen Matching in Thailand for the Prevention of Thalassemia and Subsequent Curative Hematopoietic Stem Cell Transplantation of Ten Affected Siblings

摘要

Thalassemia is the most common monogenic disease worldwideand is rampant in Southeast Asia, including Thailand. Affectedpatients require lifelong palliation and are curable only by hematopoieticstem cell transplantation (HSCT). Preimplantation withgenetic diagnosis (PGD) with human leukocyte antigen (HLA)match (PGD-HLA) can establish a pregnancy with an unaffectedand HLA-compatible embryo, the HSCs of which, when successfullyborn, can be used in a curative HSCT of an affected sibling.