Introduction: Hamartomas are non-neoplastic lesions and they can be noted in any part of the body. Hamartomas involvinghead-neck region are relatively rare. They usually depict the overgrowth of tissue indigenous to the native area. There are alsoseveral molecular expressions regulating the pathogenesis of odontogenic hamartomas and often these findings are suggestiveof the hamartomatous nature of these lesions. They should be properly differentiated from choristoma, teratoma, benignand malignant lesion.Objective: To discuss the pathogenesis of different odontogenic hamartomas to delineate their true biological behavior.Materials and methods: Data were obtained and analyzed from previously published literature and electronic databasesearches from PubMed and Google Scholar.Conclusion: Proper diagnosis of hamartomas involving the oral cavity is of utmost importance for definitive treatment modalities.Hamartomas can produce a diagnostic dilemma and overtreatment or under treatment can be a result of improperdiagnosis of hamartoma. Here, in this brief review the pathogenesis of odontogenic hamartomatous lesions involving the oralcavity are discussed.
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