Blood platelets and resident neurons are fundamentally differentcells, with peculiar features in embryological origin, function, andlocalization. However, they share common characteristics in subcellularorganization and in protein composition.1 One of the most intriguingobservations is that several proteins are typically expressedin both neurons and circulating platelets. In the latter, their concentrationsare unusually high, and they are found to regulate processessuch as platelet activation, hemostasis, and thrombosis.
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