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Venous thromboembolism in critically Ill patients with COVID‐19: Results of a screening study for deep vein thrombosis

机译:患有Covid-19患者的静脉血栓栓塞中的血栓栓塞患者:深静脉血栓形成的筛选研究结果

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Background The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), and coronavirus disease 2019 (COVID‐19), has caused more than 3.9 million cases worldwide. Currently, there is great interest to assess venous thrombosis prevalence, diagnosis, prevention, and management in patients with COVID‐19. Objectives To determine the prevalence of venous thromboembolism (VTE) in critically ill patients with COVID‐19, using lower limbs venous ultrasonography screening. Methods Beginning March 8, we enrolled 25 patients who were admitted to the intensive care unit (ICU) with confirmed SARS‐CoV‐2 infections. The presence of lower extremity deep vein thrombosis (DVT) was systematically assessed by ultrasonography between day 5 and 10 after admission. The data reported here are those available up to May 9, 2020. Results The mean (± standard deviation) age of the patients was 68?±?11?years, and 64% were men. No patients had a history of VTE. During the ICU stay, 8 patients (32%) had a VTE; 6 (24%) a proximal DVT, and 5 (20%) a pulmonary embolism. The rate of symptomatic VTE was 24%, while 8% of patients had screen‐detected DVT. Only those patients with a documented VTE received a therapeutic anticoagulant regimen. As of May 9, 2020, 5 patients had died (20%), 2 remained in the ICU (8%), and 18 were discharged (72%). Conclusions In critically ill patients with SARS‐CoV‐2 infections, DVT screening at days 5‐10 of admission yielded a 32% prevalence of VTE. Seventy‐five percent of events occurred before screening. Earlier screening might be effective in optimizing care in ICU patients with COVID‐19.
机译:背景技术重症急性呼吸综合征冠状病毒2(SARS-COV-2)和冠状病毒疾病2019(Covid-19)的快速传播已在全球超过390万个案件。目前,有兴趣评估Covid-19患者的静脉血栓形成患病率,诊断,预防和管理。目的是使用下肢静脉超声筛查确定患有Covid-19的静脉血栓栓塞(VTE)的患病率。方法从3月8日开始,我们注册了25名患者,被确认的SARS-COV-2感染进入重症监护病房(ICU)。通过在入院后的第5天和第10天之间通过超声检查系统地评估下肢深静脉血栓形成(DVT)的存在。这里报告的数据是最多可在2020年5月9日提供的数据。结果患者的平均值(±标准偏差)年龄为68?±11?岁月,64%是男性。没有患者有VTE的历史。在ICU住宿期间,8名患者(32%)有VTE; 6(24%)近端DVT,5(20%)肺栓塞。症状VTE的速率为24%,而8%的患者进行了屏幕检测到的DVT。只有那些记录的VTE患者接受了治疗性抗凝血剂方案。截至2020年5月9日,5名患者死亡(20%),2例残留在ICU(8%)中,18例(72%)。结论患有SARS-COV-2感染的危重患者,入院时间5-10天的DVT筛选产生了32%的VTE患病率。在筛选之前,百分之七十五的事件发生。早期的筛查可能有效地在Covid-19患者优化ICU患者的护理方面有效。
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