In addition to its fundamental role in human fertilization,the fallopian tube has recently been associatedwith the risk of epithelial ovarian cancer, the most aggressiveand deadly gynecological malignancy. Substantialevidence, based on combined morphological and moleculardata, indicates that the distal fallopian tube (fimbria),rather than the ovarian surface epithelium, is the locationof origin of most low- and high-grade serous ovariancarcinomas(1,2). The tubal fimbria and ovarian epitheliumhave similar histological characteristics and immunohistochemicalmarkers, supporting the hypothesis that, embryologically,the fimbria arise separately from the rest ofthe fallopian tube(3).
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