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Electron beam scattering device for FLASH preclinical studies with 6-MeV LINAC

机译:用于闪光灯型研究的电子束散射装置,用6-MeV LinaC进行临床前研究

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In this study, an electron-scattering device was fabricated to practically use the ultra-high dose rate electron beams for the FLASH preclinical research in Dongnam Institute of Radiological and Medical Sciences. The Dongnam Institute of Radiological and Medical Sciences has been involved in the investigation of linear accelerators for preclinical research and has recently implemented FLASH electron beams. To determine the geometry of the scattering device for the FLASH preclinical research with a 6-MeV linear accelerator, the Monte Carlo N-particle transport code was exploited. By employing the fabricated scattering device, the off-axis and depth dose distributions were measured with radiochromic films. The generated mean energy of electron beams via the scattering device was 4.3?MeV, and the symmetry and flatness of the off-axis dose distribution were 0.11% and 2.33%, respectively. Finally, the doses per pulse were obtained as a function of the source to surface distance (SSD); the measured dose per pulse varied from 4.0 to 0.2?Gy/pulse at an SSD range of 20–90?cm. At an SSD of 30?cm with a 100-Hz repetition rate, the dose rate was 180?Gy/s, which is sufficient for the preclinical FLASH studies.
机译:在该研究中,制造了一种电子散射装置,以实际使用超高剂量率电子束来换取东脊放射医学研究所的闪光临床前研究。东南放射医学研究所一直参与了临床前研究线性加速器的调查,最近实施了闪光电子束。为了确定具有6 Mev线性加速器的Flash临床前研究的散射装置的几何形状,蒙特卡罗N-粒子传输代码被利用。通过采用制造的散射装置,用放射褐色膜测量偏离轴和深度剂量分布。经由散射装置的电子束的产生的平均能量为4.3μm,偏离轴剂量分布的对称性和平坦度分别为0.11%和2.33%。最后,获得每个脉冲的剂量作为表面距离(SSD)的源极;每个脉冲的测量剂量在20-90Ω·厘米的SSD范围内的4.0至0.2Ω·GY /脉冲变化。在具有100 Hz重复率的30厘米的SSD,剂量率为180Ω·GY / s,这足以用于临床前闪光研究。

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