Therapeutic Implications of Renal Biopsies to Detect Proliferative Lupus Nephritis in Patients With Low-Grade Proteinuria

摘要

To the Editor: In their research letter, de Rosa et al. 1 present important data in a cohort of patients with lupus nephritis (LN) with low-grade proteinuria. They demonstrate that a significant proportion of patients requiring intensive immunosuppressive therapy may be missed with a threshold of 500 mg/24 hours of proteinuria as an indication for renal biopsy, as sug- gested in the latest European League Against Rheu- matism guideline. 2 They show that 46 of 228 patients who underwent a renal biopsy had low-grade pro- teinuria and microscopic hematuria. Of these, 84.8% had proliferative LN.