eritoneal dialysis (PD) patients have a distinct ure- Pmic toxin profile and metabolic abnormalities, which could be related in part to the differences in gut microbiota. 1 Prebiotics are microbial feed supplements that beneficially affect the host by improving its intestinal microbial balance and re-establishing symbi- osis. Treatment with the prebiotic, oligofructose- enriched p-inulin (p-inulin) is believed to enable proliferation of beneficial gut bacteria such as Bifido- bacteria, to attenuate inflammation, and to improve metabolicfunctions. 2,3 Theaimsofthispilotstudyare(i) to compare the microbiome profile in PD patients and individuals without kidney disease, and (ii) to evaluate the effect of p-inulin treatment on inflammatory biomarkers and microbiome community composition and to associate it with host metabolomic profile.
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