Lead (Pb) is known to disrupt biochemical and physiological functions,which leads to the dysfunction.The objective of this experiment was to evaluate the choice of porphyrin profile as non-destructive biomarkers in excreta of rabbit for assessing mammal exposure to lead.Twenty-four white rabbits (12/12 females/males) were gathered according to their sex into three groups; one control and two groups exposed to two doses (1/100 and 1/50 of LDso).Feces of all groups were tested at the start of the experiment (To),and every 10 days till the end of the experiment (Tio,T20,T30).The obtained results were characterized by significantly increased concentrations of coproporphyrin (CP) and 7-carboxy-porphyrin (7-CBX) with a clear predominance of uroporphyrin I (UPI) respect to their control.To infer,a key finding in this study was usefulness of porphyrin profiles in male populations exposed to lead acetate as non-destructive biomarkers.
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