It is common to consider using a data-intensive strategy as a way to develop systemic and quantitative analysis of complex systems, so that data collection, sampling, standardization, visualization, and interpretation can determine how causal relationships are identified and incorporated into mathematical models. Collecting enough large data sets seems to be a good strategy in reducing bias of the collected data; but persistent and dynamic anomalies in the data structure, generated from variations in intrinsic mechanisms, can actually induce a persistent entropy thus affecting the overall validity of quantitative models. In this research, we are introducing a method based on the definition of homological groups aim at evaluating this persistent entropy as a complexity measure to estimate the observability of the systems. This method identifies patterns with persistent topology, extracted from the combination of different time series and clustering them to identify persistent bias in the data. We tested this method on accumulated data from patients using mobile sensors to measure the response of physical exercise in real-world conditions outside the lab. With this method, we aim to better stratify time series and customize models in complex -biological- systems.
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