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A Simulation of a COVID-19 Epidemic Based on a Deterministic SEIR Model

机译:基于确定性SEIR模型的Covid-19流行病的模拟

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An epidemic disease caused by a new coronavirus has spread in Northern Italy with a strong contagion rate. We implement an SEIR model to compute the infected population and number of casualties of this epidemic. We perform an analysis of the results of the model, by varying the parameters and initial conditions. We consider the Lombardy case and calibrate the model with the number of dead individuals to date (May 5, 2020) and constraint the parameters on the basis of values reported in the literature. The peak occurs at day 37 (March 31) approximately with a reproduction ratio R0 = 3 initially, 1.36 at day 22 and 0.8 after day 35, indicating different degrees of lockdown. The predicted death toll is approximately 15600 casualties, with 2.7 million infected individuals at the end of the epidemic. The incubation period providing a better fit of the dead individuals is 4.25 days and the infectious period is 4 days, with a fatality rate of 0.00144/day [values based on the reported (official) number of casualties]. The infection fatality rate (IFR) is 0.57 %, and 2.37 % if twice the reported number of casualties is assumed. However, these rates depend on the initially exposed individuals. If approximately nine times more individuals are exposed, there are three times more infected people at the end of the epidemic and IFR = 0.47 %. If we relax these constraints and use a wider range of lower and upper bounds for the incubation and infectious periods, we observe that a higher incubation period (13 versus 4.25 days) gives the same IFR (0.6 % versus 0.57 %), but nine times more exposed individuals in the first case. Other choices of the set of parameters also provide a good fit of the data, but some of the results may not be realistic. Therefore, an accurate determination of the fatality rate and characteristics of the epidemic is subject to the knowledge of precise bounds of the parameters.
机译:由新的冠状病毒引起的流行病患者在意大利北部具有强大的传感率。我们实施SEIR模型以计算受感染的人口和这种流行病的伤亡人数。通过改变参数和初始条件,我们对模型结果进行分析。我们考虑伦巴第案例,并将模型与日期(5月5,2020)(5月5,2020)进行校准,并基于文献中报告的值约束参数。峰值在第37天(3月31日)发生在第32天的再现比率R0 = 3,第22天和第35天之后的第32天和0.8,表示不同程度的锁定。预测的死亡人数约为15600人伤亡,在流行病的尽头有270万感染者。提供更好的死亡人员的潜伏期为4.25天,传染期为4天,死亡率为0.00144 /天[基于报告(官方)伤亡人数的值]。如果假设报告的伤亡人数是两倍的话,感染死亡率(IFR)为0.57%,2.37%。然而,这些税率取决于最初暴露的个体。如果曝光大约9次,则流行病结束时有三倍的感染者,IFR = 0.47%。如果我们放松这些约束并使用更广泛的下限和上界进行培养和传染期,我们观察到更高的培养期(13与4.25天)给出相同的IFR(0.6%,而0.57%),但九次在第一种情况下更暴露的人。这些参数集的其他选择也提供了良好的数据拟合,但其中一些结果可能不是现实的。因此,准确确定流行病的死亡率和特征受到参数的精确范围的知识。

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